Cajun Chicken Alfredo

Featured in: Comfortable Everyday Meals

Cajun Chicken Alfredo brings together the bold flavors of the South with Italian comfort in one stunning dish. Tender chicken breasts are seasoned with warm Cajun spices and seared to golden perfection, while a silky cream sauce enriched with garlic, butter, and Parmesan comes together in minutes. Toss it all with al dente pasta and fresh parsley for a restaurant-quality meal that's surprisingly simple to prepare at home.

Updated on Sun, 18 Jan 2026 09:20:00 GMT
Creamy Cajun Chicken Alfredo with tender, spice-rubbed chicken strips and fettuccine coated in a rich Parmesan sauce. Pin it
Creamy Cajun Chicken Alfredo with tender, spice-rubbed chicken strips and fettuccine coated in a rich Parmesan sauce. | ovendrift.com

The smoke alarm went off halfway through my first attempt at this dish, and I nearly tossed the whole pan in frustration. But once I learned to control the heat and let the Cajun spices bloom without burning, everything clicked. Now it's the recipe I make when I want to impress without spending hours in the kitchen. That balance of creamy richness and bold spice feels like a celebration on a weeknight.

I made this for a friend's birthday dinner last spring, and she kept asking what restaurant I ordered it from. When I told her I'd cooked it myself, she made me write down the recipe on a napkin. That napkin is probably still tucked in her kitchen drawer somewhere. It's the kind of dish that makes people lean back in their chairs and sigh contentedly.

Ingredients

  • Boneless, skinless chicken breasts: I slice them thinner if they're especially thick so they cook evenly and soak up the seasoning better.
  • Cajun seasoning: The soul of this dish, it should have a mix of paprika, garlic, onion, and cayenne for that proper kick.
  • Olive oil: Just enough to get a good sear on the chicken without making it greasy.
  • Fettuccine or linguine: Wide noodles hold onto the sauce beautifully, though I've used penne in a pinch and it still worked.
  • Unsalted butter: Lets you control the salt level, especially important since Parmesan is naturally salty.
  • Garlic cloves: Fresh is non-negotiable here, the jarred stuff just doesn't have the same punch.
  • Heavy cream: This is what makes the sauce luscious and smooth, don't try to swap it for milk.
  • Freshly grated Parmesan cheese: Pre-shredded cheese has anti-caking agents that make the sauce grainy, so grate it yourself if you can.
  • Black pepper and salt: Season carefully, the Cajun blend already brings salt to the table.
  • Red pepper flakes: Optional, but I like the extra warmth they add to the background.
  • Fresh parsley: Brightens the whole plate and cuts through the richness with a fresh note.

Instructions

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Cook the pasta:
Bring a large pot of salted water to a rolling boil and add the fettuccine, cooking until it's just al dente with a slight bite. Reserve half a cup of that starchy pasta water before draining, it's your secret weapon for adjusting the sauce later.
Prepare the chicken:
Pat the chicken breasts completely dry with paper towels, then rub the Cajun seasoning all over until every inch is coated. Dry chicken sears better and creates that beautiful golden crust.
Sear the chicken:
Heat olive oil in a large skillet over medium-high heat until it shimmers, then lay the chicken in gently and let it cook undisturbed for five to six minutes per side. You'll know it's ready when it reaches 165 degrees inside and has a spiced, caramelized crust.
Rest and slice:
Pull the chicken from the skillet and let it rest for a few minutes so the juices redistribute. Slice it into strips against the grain for the most tender bites.
Make the Alfredo sauce:
Melt butter in the same skillet over medium heat, then add the minced garlic and stir for just thirty seconds until it smells incredible. Pour in the heavy cream while whisking constantly and bring it to a gentle simmer without letting it boil over.
Finish the sauce:
Stir in the Parmesan, black pepper, salt, and red pepper flakes if you're using them, then let it simmer for two to three minutes until it thickens enough to coat the back of a spoon. If it gets too thick, add reserved pasta water a tablespoon at a time until it's silky.
Combine and serve:
Toss the cooked pasta into the skillet and coat it well with the sauce, then add the sliced Cajun chicken and toss again. Serve immediately with a sprinkle of chopped parsley and extra Parmesan on top.
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Golden, Cajun-seasoned chicken slices rest on silky Alfredo-coated pasta, garnished with fresh parsley for a vibrant, aromatic touch. Pin it
Golden, Cajun-seasoned chicken slices rest on silky Alfredo-coated pasta, garnished with fresh parsley for a vibrant, aromatic touch. | ovendrift.com

One night I made this for my brother, who usually only eats chicken wings and pizza. He scraped his plate clean and asked if there was more in the kitchen. Watching him twirl fettuccine around his fork like he'd been doing it his whole life made me realize food has a way of surprising people. It's not just dinner, it's a little moment of joy.

How to Store and Reheat

I store leftovers in an airtight container in the fridge for up to three days, though it rarely lasts that long. When reheating, I add a splash of cream or milk to the pan over low heat and stir gently until it's warmed through and silky again. The microwave works in a pinch, but the stovetop brings the sauce back to life much better.

Swaps and Variations

If you want to sneak in some vegetables, sautéed bell peppers or a handful of fresh spinach stirred in at the end work beautifully. I've also swapped the chicken for shrimp when I'm craving seafood, and it cooks even faster. For a lighter version, you can use half-and-half instead of heavy cream, though the sauce won't be quite as rich. One friend of mine uses blackened tofu instead of chicken and swears by it.

Pairing Suggestions

This dish loves a crisp white wine like Sauvignon Blanc or a buttery Chardonnay to balance the spice and richness. I usually serve it with a simple green salad dressed in lemon vinaigrette to cut through the creaminess. Garlic bread on the side is never a bad idea, especially for soaking up any extra sauce left on the plate.

  • A light arugula salad with lemon and olive oil keeps things fresh.
  • Roasted asparagus or green beans add a nice crunch.
  • Crusty bread for mopping up every last bit of Alfredo sauce.
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A hearty skillet of Cajun Chicken Alfredo pasta, topped with extra Parmesan, perfect for a comforting weeknight dinner. Pin it
A hearty skillet of Cajun Chicken Alfredo pasta, topped with extra Parmesan, perfect for a comforting weeknight dinner. | ovendrift.com

This recipe has become my go-to for nights when I want comfort with a little bit of excitement. It reminds me that you don't have to choose between cozy and bold, sometimes the best meals are both.

Recipe FAQ

Can I make this dish ahead of time?

This dish is best served immediately after combining the pasta, sauce, and chicken. However, you can prepare the components separately and assemble just before serving. Store cooked chicken in the refrigerator for up to 3 days.

How do I prevent the Alfredo sauce from breaking?

Keep the heat at medium or below and whisk constantly when adding the cream. Avoid boiling the sauce, as high heat can cause the cream and cheese to separate. If the sauce does break, remove from heat and whisk in a splash of pasta water.

What can I substitute for heavy cream?

Half-and-half works well as a lighter alternative, though the sauce will be less rich. You can also use a combination of milk and butter, or cashew cream for a dairy-free option. Adjust the consistency as needed with pasta water.

Is there a way to make this less spicy?

Reduce the amount of Cajun seasoning on the chicken or use a milder seasoning blend. Omit the red pepper flakes entirely and taste before adjusting. You can always add more heat, but it's harder to remove.

What side dishes pair well with this?

A crisp green salad with lemon vinaigrette balances the richness nicely. Garlic bread is a classic pairing, or try roasted vegetables like broccoli and asparagus. A chilled white wine such as Sauvignon Blanc complements the dish beautifully.

Can I use a different pasta shape?

Absolutely. Pappardelle, tagliatelle, or even penne work wonderfully. Avoid very thin pastas like angel hair, as they may become mushy. Choose pasta that holds the creamy sauce well.

Cajun Chicken Alfredo

Spicy Cajun-seasoned chicken combined with creamy Alfredo sauce and fettuccine pasta. A Southern-Italian fusion comfort dish.

Prep time
15 min
Time to cook
25 min
Total duration
40 min
Created by Landen Phillips


Skill level Medium

Cuisine type American Cajun-Italian Fusion

Makes 4 Portions

Diet details None specified

What You’ll Need

Chicken

01 2 large boneless, skinless chicken breasts
02 1 tablespoon Cajun seasoning
03 1 tablespoon olive oil

Pasta

01 12 ounces fettuccine or linguine pasta

Alfredo Sauce

01 2 tablespoons unsalted butter
02 3 cloves garlic, minced
03 1.5 cups heavy cream
04 1 cup freshly grated Parmesan cheese
05 0.25 teaspoon ground black pepper
06 0.25 teaspoon salt
07 0.25 teaspoon red pepper flakes, optional

Garnish

01 2 tablespoons chopped fresh parsley
02 Extra grated Parmesan cheese for serving

How-To

Step 01

Cook pasta: Bring a large pot of salted water to a boil. Add fettuccine and cook according to package instructions until al dente. Reserve 0.5 cup pasta water and drain remaining water. Set aside.

Step 02

Prepare chicken: Pat chicken breasts dry and rub evenly with Cajun seasoning.

Step 03

Sear chicken: Heat olive oil in a large skillet over medium-high heat. Add chicken breasts and cook 5-6 minutes per side until golden and cooked through, reaching internal temperature of 165°F. Remove from skillet, rest 2-3 minutes, then slice into strips.

Step 04

Create Alfredo sauce: In the same skillet over medium heat, melt butter. Add minced garlic and sauté 30 seconds until fragrant. Pour in heavy cream, whisking constantly, and bring to gentle simmer without boiling.

Step 05

Season sauce: Stir in Parmesan cheese, black pepper, salt, and red pepper flakes if using. Simmer 2-3 minutes until sauce thickens. Add reserved pasta water one tablespoon at a time if sauce becomes too thick.

Step 06

Combine components: Add cooked pasta to skillet and toss well to coat with Alfredo sauce. Add sliced Cajun chicken and toss again.

Step 07

Serve: Plate immediately and garnish with chopped parsley and extra Parmesan cheese.

Needed Tools

  • Large pot
  • Large skillet
  • Tongs
  • Chef's knife
  • Cutting board
  • Measuring cups and spoons
  • Whisk

Allergy details

Make sure to review each item for allergens. Check with a healthcare provider if you have questions.
  • Contains milk: heavy cream, butter, Parmesan cheese
  • Contains wheat: pasta
  • May contain eggs if using fresh pasta
  • Verify Cajun seasoning for gluten or additional allergens if sensitive

Nutrition info (each serving)

This info’s for reference only and isn’t medical advice.
  • Calories: 670
  • Fats: 34 g
  • Carbohydrates: 54 g
  • Proteins: 40 g